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com. The neck is divided into three anatomic zones. Biosynthesis of 2-AG Two possible pathways for the biosynthesis of 2-AG have been proposed: (1) a phospholipase C (PLC) hydrolysis of membrane phospholipids followed by a second hydrolysis of the resulting 1,2-diacylglycerol by diacylglycerol lipase or (2) a phospholipase A1 (PLA1) activity that generates a lysophospholipid, which in turn is hydrolyzed to 2-AG by lysophospholipase C (Fig.
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